Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Quercetin
500 mg
†
Top Medical Research Studies
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
Read More
9
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Read More
8
We investigated how quercetin can help protect kidneys from damage caused by diabetes in rats. Our study involved forty male Wistar rats divided into different groups to compare the effects of quercetin treatment before and after diabetes was induced.
We found that quercetin significantly reduced kidney dysfunction symptoms and oxidative stress markers compared to untreated diabetic rats. This improvement linked to quercetin's ability to enhance antioxidant defenses and disrupt harmful signaling pathways. However, we observed that pretreatment with quercetin was more effective than post-treatment, suggesting timing matters in its effectiveness.
We found that quercetin significantly reduced kidney dysfunction symptoms and oxidative stress markers compared to untreated diabetic rats. This improvement linked to quercetin's ability to enhance antioxidant defenses and disrupt harmful signaling pathways. However, we observed that pretreatment with quercetin was more effective than post-treatment, suggesting timing matters in its effectiveness.
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Most Useful Reviews
9
Symptom relief
87 people found this helpful
Close to magic! After struggling with severe adrenal fatigue and an autoimmune disorder, I found Quercetin to be miraculous. During a mastocytosis attack, it outperformed over-the-counter histamine blockers, preventing allergic reactions even with previously offending foods. I recommend it for anyone suffering from allergies, but be cautious with dosage. The quality is impeccable, and I am nearly symptom-free.
Read More
9
Breathing improvement
4 people found this helpful
Amazing for asthma! This supplement helps me breathe better, and I've experienced fewer skin issues since I started taking it.
Read More
7.5
Prevention tool
9 people found this helpful
Great pure quercetin! My husband takes it to prevent prostatitis, while I use it for blood vessel health and immunity alongside zinc. We've relied on this pure, additive-free product for seven years.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
Read More
9
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Read More
9
We explored how Sendeng-4, a traditional Mongolian medicine, can ease rheumatoid arthritis (RA). By using advanced methods to analyze its active components, we identified key phytochemicals and mapped their effects on biological pathways.
After testing on a rat model of RA, we observed that Sendeng-4 significantly reduces inflammation and arthritis symptoms, particularly through the PI3K-Akt signaling pathway. Overall, this study reveals Sendeng-4's potential benefits in treating RA and encourages further research into traditional remedies.
After testing on a rat model of RA, we observed that Sendeng-4 significantly reduces inflammation and arthritis symptoms, particularly through the PI3K-Akt signaling pathway. Overall, this study reveals Sendeng-4's potential benefits in treating RA and encourages further research into traditional remedies.
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9
Quercetin liposomes aid diabetes therapy
We observed that a new form of quercetin, delivered in lipid nanoparticles, can help alleviate diabetes symptoms in rats. This improved bioavailable quercetin significantly reduced blood glucose levels and lowered pancreatic oxidative stress and inflammation.
It also enhanced autophagy while reducing endoplasmic reticulum stress markers. However, when combined with an autophagy inhibitor, the positive effects disappeared, indicating the importance of autophagy in quercetin’s benefits. Overall, this study highlights the potential of quercetin liposomes in managing type 1 diabetes.
It also enhanced autophagy while reducing endoplasmic reticulum stress markers. However, when combined with an autophagy inhibitor, the positive effects disappeared, indicating the importance of autophagy in quercetin’s benefits. Overall, this study highlights the potential of quercetin liposomes in managing type 1 diabetes.
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8
Quercetin shows promise for RA treatment
We examined the active components in the Additive Sishen Decoction (ASSD), a traditional Chinese medicine for rheumatoid arthritis (RA). Our findings revealed that key ingredients—quercetin, kaempferol, and luteolin—play a significant role in reducing inflammation through specific pathways.
These ingredients inhibit proinflammatory factors by affecting glucose metabolism in macrophages. We employed protein interaction networks and molecular simulations to clarify their mechanisms, showing that quercetin contributes significantly to ASSD’s therapeutic effects.
Overall, we established that quercetin can be a valuable aid in managing RA symptoms.
These ingredients inhibit proinflammatory factors by affecting glucose metabolism in macrophages. We employed protein interaction networks and molecular simulations to clarify their mechanisms, showing that quercetin contributes significantly to ASSD’s therapeutic effects.
Overall, we established that quercetin can be a valuable aid in managing RA symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Symptom relief
87 people found this helpful
Close to magic! After struggling with severe adrenal fatigue and an autoimmune disorder, I found Quercetin to be miraculous. During a mastocytosis attack, it outperformed over-the-counter histamine blockers, preventing allergic reactions even with previously offending foods. I recommend it for anyone suffering from allergies, but be cautious with dosage. The quality is impeccable, and I am nearly symptom-free.
Read More
9
Breathing improvement
4 people found this helpful
Amazing for asthma! This supplement helps me breathe better, and I've experienced fewer skin issues since I started taking it.
Read More
7.5
Prevention tool
9 people found this helpful
Great pure quercetin! My husband takes it to prevent prostatitis, while I use it for blood vessel health and immunity alongside zinc. We've relied on this pure, additive-free product for seven years.
Read More
7.5
Effective for vasculitis
3 people found this helpful
My husband has an autoimmune disorder with vasculitis but improved significantly since taking this product. It also alleviates itchiness, acne, and rhinitis, making it a great ingredient for inflammation.
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7.5
Allergy control
3 people found this helpful
Helpful for our allergies! We have relied on this brand for years because it consistently provides better results than others. A daily dose greatly improves our productivity, even in allergy season.
Read More
Frequently Asked Questions
7.5
Effective for vasculitis
3 people found this helpful
My husband has an autoimmune disorder with vasculitis but improved significantly since taking this product. It also alleviates itchiness, acne, and rhinitis, making it a great ingredient for inflammation.
7.5
Flushing reduction
3 people found this helpful
Quercetin 500mg capsules are extremely helpful for my mast cell disorder. They reduce flushing, brain fog, and increase my energy levels.
6
Antihistamine substitute
2 people found this helpful
I hoped to replace antihistamines for my unclear allergy. Though still taking Zyrtec, I feel some relief in my eyes after just 10 days of use.
9
Symptom relief
87 people found this helpful
Close to magic! After struggling with severe adrenal fatigue and an autoimmune disorder, I found Quercetin to be miraculous. During a mastocytosis attack, it outperformed over-the-counter histamine blockers, preventing allergic reactions even with previously offending foods. I recommend it for anyone suffering from allergies, but be cautious with dosage. The quality is impeccable, and I am nearly symptom-free.
9
Breathing improvement
4 people found this helpful
Amazing for asthma! This supplement helps me breathe better, and I've experienced fewer skin issues since I started taking it.
7.5
Allergy control
3 people found this helpful
Helpful for our allergies! We have relied on this brand for years because it consistently provides better results than others. A daily dose greatly improves our productivity, even in allergy season.
0
Not suitable for me
3 people found this helpful
I ordered this as it is recommended for hay fever and allergies, and it has received great reviews from many. Unfortunately, I couldn't tolerate it. I am sensitive to supplements in general and felt overly stimulated on Quercetin. I discontinued it after a few days.
7.5
Prevention tool
9 people found this helpful
Great pure quercetin! My husband takes it to prevent prostatitis, while I use it for blood vessel health and immunity alongside zinc. We've relied on this pure, additive-free product for seven years.
7.5
Adrenal support
2 people found this helpful
Quality product at a reasonable price! I ordered it for my aunt with adrenal issues on a doctor's recommendation. She reports significant help after taking two capsules a day.
9
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
8
Quercetin combined with chondroitin sulfate
We examined how quercetin interacts with chondroitin sulfate to potentially alleviate rheumatoid arthritis, a challenging autoimmune disorder linked to bacterial aggressors like Proteus mirabilis. This study utilized both in vitro and in vivo methods to identify their combined effects.
The results indicated that these compounds could reduce inflammation and oxidative stress while showing promising antibacterial properties. Zebrafish treated with the combination exhibited better survival rates under bacterial stress and showed significant metabolic improvements. Overall, it appears that quercetin and chondroitin sulfate might be valuable in managing this condition, but further research is needed to fully understand their benefits.
The results indicated that these compounds could reduce inflammation and oxidative stress while showing promising antibacterial properties. Zebrafish treated with the combination exhibited better survival rates under bacterial stress and showed significant metabolic improvements. Overall, it appears that quercetin and chondroitin sulfate might be valuable in managing this condition, but further research is needed to fully understand their benefits.
References
- Ren J, Liu Z, Qi X, Meng X, Guo L, et al. Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimental Verification. Drug Des Devel Ther. 2025;19:405. doi:10.2147/DDDT.S489323
- Yang J, Yang H, Wang F, Dai Y, Deng Y, et al. Bioinformatics identification based on causal association inference using multi-omics reveals the underlying mechanism of Gui-Zhi-Shao-Yao-Zhi-Mu decoction in modulating rheumatoid arthritis. Phytomedicine. 2025;136:156332. doi:10.1016/j.phymed.2024.156332
- Zhendong Y, Changjun C, Haocheng H, Qibin L, Dailing C, et al. Regulation of macrophage polarization and pyroptosis by 4-methylcatechol alleviates collagen-induced arthritis via Nrf2/HO-1 and NF-κB/NLRP3 signaling pathways. Int Immunopharmacol. 2025;146:113855. doi:10.1016/j.intimp.2024.113855
- Priya PS, Murugan R, Srileka R, Ramya Ranjan Nayak SP, Margesan T, et al. Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms. Microb Pathog. 2024;197:107086. doi:10.1016/j.micpath.2024.107086
- Xiong F, Shen K, Long D, Zhou S, Ruan P, et al. Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway. Immun Ageing. 2024;21:69. doi:10.1186/s12979-024-00474-9
- Karnam S, Jindal AB, Paul AT. Quality by design-based optimization of teriflunomide and quercetin combinational topical transferosomes for the treatment of rheumatoid arthritis. Int J Pharm. 2024;666:124829. doi:10.1016/j.ijpharm.2024.124829
- Zhang F, Zhang Y, Zhou J, Cai Y, Li Z, et al. Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling. Mol Med. 2024;30:170. doi:10.1186/s10020-024-00929-1
- Wu Z, Hu J, Li Y, Yao X, Ouyang S, et al. Assessment of renal pathophysiological processes and protective effect of quercetin on contrast-induced acute kidney injury in type 1 diabetic mice using diffusion tensor imaging. Redox Rep. 2024;29:2398380. doi:10.1080/13510002.2024.2398380
- Guo X, Wu W, Ran Q, Wang L, Li Y, et al. Exploring the pharmacological mechanisms of the flower of Rhododendron molle in rheumatoid arthritis rats based on metabolomics integrated network pharmacology. J Ethnopharmacol. 2024;334:118524. doi:10.1016/j.jep.2024.118524
- Pei C, Yu J, Wang G, Jia YR, Shi X, et al. Exploring the mechanism of Sendeng-4 against rheumacid arthritis through integrated serum pharmacochemistry, transcriptomics, and network pharmacology. Biomed Chromatogr. 2024;38:e5893. doi:10.1002/bmc.5893
- Zhou F, Guo YX, Gao R, Ji XY, Tang YX, et al. Quercetin regulates dendritic cell activation by targeting STAT4 in the treatment of experimental autoimmune encephalomyelitis. Toxicol Appl Pharmacol. 2024;488:116980. doi:10.1016/j.taap.2024.116980
- Hossein A, Firouzeh G, Zeinab K, Gholamreza D. Quercetin prevents kidney against diabetes mellitus (type 1) in rats by inhibiting TGF-β/apelin gene expression. Mol Biol Rep. 2024;51:677. doi:10.1007/s11033-024-09617-z
- Hou Y, Chen C, Li Z, Wu J, Lyu S, et al. Protective effect of quercetin against macrophage-mediated hepatocyte injury via anti-inflammation, anti-apoptosis and inhibition of ferroptosis. Autoimmunity. 2024;57:2350202. doi:10.1080/08916934.2024.2350202
- Li X, Wang X, Qu X, Shi N, Li Q, et al. Microenvironmental Enzyme-Responsive Methotrexate Modified Quercetin Micelles for the Treatment of Rheumatoid Arthritis. Int J Nanomedicine. 2024;19:3259. doi:10.2147/IJN.S457004
- Chen J, Huang C, Li M. [ granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]. Nan Fang Yi Ke Da Xue Xue Bao. 2024;44:465. doi:10.12122/j.issn.1673-4254.2024.03.07
- Khater SI, El-Emam MMA, Abdellatif H, Mostafa M, Khamis T, et al. Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress - unfolded protein response (UPR) - autophagy, and their regulatory miRNA. Life Sci. 2024;344:122546. doi:10.1016/j.lfs.2024.122546
